Article

Surprising variation in the outcome of two malaria genetic crosses using humanized mice: implications for genetic mapping and malaria biology

2019-12-13

Abstract excerpt

Genetic crosses are most powerful for linkage analysis when progeny numbers are high, when parental alleles segregate evenly and, for hermaphroditic organisms, when numbers of inbred progeny are minimized. We previously developed a novel genetic crossing platform for the human malaria parasite Plasmodium falciparum , an obligately sexual, hermaphroditic protozoan, using mice carrying human hepatocytes (the human...

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Literature Corpus work: de2a189a-b927-5a11-9a91-bd387a08dbc2
DOI: 10.1101/2019.12.13.871830

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