Article

HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Regulatory T (Treg) cells expressing RORγt accumulate in the intestinal mucosa, yet the signals that determine whether they remain suppressive or acquire inflammatory features are incompletely defined. We first reanalyzed human ileal single-cell data and identified Crohn’s disease–enriched FOXP3⁺ states in which RORC, HIF1A, hypoxia-responsive, inflammatory, and metabolic programs converged. We...

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Literature Corpus work: de0acdc7-b6bf-57d9-b077-1eb6f963a69c
DOI: 10.64898/2026.08.11.744213

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