Article

Acetoacetate suppresses colon cancer via an MR1-MAIT axis

2025-10-30

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal cancer (CRC) is a leading cause of cancer mortality and additional preventative, and therapeutic strategies are urgently needed. Ketogenic diets have mixed effects on tumorigenesis and compliance is challenging. Exogenous ketones, β-hydroxybutyrate (βHB) or acetoacetate (AcAc), offer an alternative approach. While βHB has been investigated, the anti-cancer effects of AcAc are poorly d...

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Literature Corpus work: 5a0f551a-62b4-5b9f-a932-f22e5b22a448
DOI: 10.1101/2025.10.29.685375

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