Article

Immunity Depletion, Telomere Imbalance, and Cancer-associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Caloric Restriction

2021-03-11

Abstract excerpt

Systematic analysis of calorie restriction (CR) mechanisms and pathways in cancer biology has not been carried out, leaving therapeutic benefits unclear. Using a systems biology approach and metadata analysis, we studied gene expression changes in the response of normal mouse duodenum mucosa (DM) to short-term (2-weeks) 25% CR as a biological model. We found a high similarity of gene expression profiles in human a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c6a2c7a-ae45-564c-bd61-5834af040607
DOI: 10.1101/2021.03.10.433216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunity Depletion, Telomere Imbalance, and Cancer-associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Caloric RestrictionDOI 10.1101/2021.03.10.433216Read

Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for TumorigenesisSemantic proximity Read

Dynamic intestinal stem cell plasticity and lineage remodeling by a nutritional environment relevant to human risk for tumorigenesisSemantic proximity Read

The nutritional environment determines which and how intestinal stem cells contribute to homeostasis and tumorigenesisSemantic proximity Read

Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer ImmunotherapySemantic proximity Read

Long-Term Intestinal Epithelial Remodeling Induced by Acute Protein-Energy MalnutritionSemantic proximity Read

Metabolic reprogramming and immunosenescence in colorectal cancer: mechanisms and therapeutic implicationsSemantic proximity Read

Calorie restriction and cancer prevention: a mechanistic perspectiveSemantic proximity Read

Nutrition, inflammation and cancerSemantic proximity Read

Caloric restriction and cancer: molecular mechanisms and clinical implicationsSemantic proximity Read

Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesisSemantic proximity Read

CTLA-4 inhibitors drive colitis through metabolic reprogramming-mediated Treg/Th17 imbalanceSemantic proximity Read

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient miceSemantic proximity Read