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RNA binding protein DDX5 restricts RORγt + T reg suppressor function to promote intestine inflammation

1 Feb 2023

Abstract excerpt

Retinoid-related orphan receptor (RAR) gamma (RORγt)–expressing regulatory T cells (RORγt + T regs ) play pivotal roles in preventing T cell hyperactivation and maintaining tissue homeostasis, in part by secreting the anti-inflammation cytokine interleukin-10 (IL-10). Here, we report that hypoxia-induced factor 1α (HIF1α) is the master transcription factor for Il10 in RORγt + T regs . This critical...

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PMID: 36724232
DOI: 10.1126/sciadv.add6165

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