Article

Cellular complexity in murine ileitis: Different fibroblasts propel spatially defined ileal inflammation through TNFR1 signalling

2024-03-13

Abstract excerpt

<title>Abstract</title> <p>Crohn's disease represents a persistent inflammatory disorder primarily affecting the terminal ileum. Through the application of single-cell RNA sequencing, we unveil the intricate cellular complexities within murine TNF-dependent ileitis, developing in <italic>Tnf</italic><sup>ΔARE</sup> mice. Detailed immune cell analysis highlights B cell expansion, T cell effector reprogramming, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42ddb604-e569-5253-a5bc-35da690ea8ee
DOI: 10.21203/rs.3.rs-4016680/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular complexity in murine ileitis: Different fibroblasts propel spatially defined ileal inflammation through TNFR1 signallingDOI 10.21203/rs.3.rs-4016680/v1Read

Cellular complexity and crosstalk in murine TNF-dependent ileitis: Different fibroblast subsets propel spatially defined ileal inflammation through TNFR1 signallingSemantic proximity Read

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodelingSemantic proximity Read

TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell nicheSemantic proximity Read

Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healingSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Fibroblast Heterogeneity in Inflammatory Bowel DiseaseSemantic proximity Read

Intercellular interaction between FAP fibroblasts and CD150 inflammatory monocytes mediates fibro-stenosis in Crohn’s diseaseSemantic proximity Read

Pro-inflammatory secretome from intestinal epithelium recruits regulatory T cells for barrier defenceSemantic proximity Read

The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cellsSemantic proximity Read

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel diseaseSemantic proximity Read