Article

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

2017-11-22

Abstract excerpt

<h4>Summary</h4> Non-lymphoid tissues (NLTs) harbour a pool of adaptive immune cells, the development and phenotype of which remains largely unexplored. Here, we used single-cell RNA-seq to characterise CD4 + regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, the respective draining lymph nodes and spleen. From this data, we modelled a continuous lymphoid-to-NLT trajectory for Treg, and reconst...

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Literature Corpus work: 199bd44e-1675-52ed-aafb-573497426de0
DOI: 10.1101/217489

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