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Article

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.

Nature communications - 20 May 2020

Nichols Caitlin A, Gibson William J, Brown Meredith S, Kosmicki Jack A, Busanovich John P, Wei Hope, Urbanski Laura M, Curimjee Naomi, Berger Ashton C, Gao Galen F, Cherniack Andrew D, Dhe-Paganon Sirano, Paolella Brenton R, Beroukhim Rameen

Abstract excerpt

Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and normal cells. Here we interrogate LOH of polymorphisms in essential genes as a novel class of therapeutic targets. We hypothesized that monoallelic inactivation of...

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Identifiers

PMID: 32433464
DOI: 10.1038/s41467-020-16399-y
PMCID: PMC7239950

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