Article

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

2019-01-29

Abstract excerpt

Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and normal cells. Here we interrogate LOH of polymorphisms in essential genes as a novel class of therapeutic targets. We hypothesized that monoallelic inactivation of th...

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Literature Corpus work: 43045284-9d4c-563e-bc0f-059decabb998
DOI: 10.1101/534529

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