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Article

Sex-biased gene expression shapes sex differences in gene essentiality

2026-04-15

Abstract excerpt

Sex differences in disease incidence and progression are well documented, yet their underlying molecular mechanisms remain poorly understood. Multiple models suggest that baseline gene expression levels shape the impact of gene disruption, raising the possibility that sex-biased expression itself contributes to sex differences in cellular vulnerability. Here, we test this hypothesis by integrating sex-biased trans...

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Literature Corpus work
23c5ec94-3452-53d2-b0f9-94433e296d6f
DOI
10.64898/2026.04.13.717533
Open publication

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Sex-biased gene expression shapes sex differences in gene essentialityDOI 10.64898/2026.04.13.717533
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