Article

Germline DNA replication timing shapes mammalian genome composition

2018-02-01

Abstract excerpt

Mammalian DNA is replicated in a highly organized and regulated manner. Large, Mb-sized regions are replicated at defined times along S phase. DNA Replication Timing (RT) has been suggested to play an important role in shaping the mammalian genome by affecting mutation rates. Previous analyses relied on somatic DNA RT profiles, while to fully understand the influences of RT on the mammalian genome, germ cell RT in...

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Literature Corpus work: ddc68318-6600-502f-bb75-7c7a182052c6
DOI: 10.1101/258426

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