Article

Germline DNA replication shapes the recombination landscape in mammals

2020-09-23

Abstract excerpt

<h4>Summary:</h4> Genetic recombination generates novel trait combinations and understanding how recombination is distributed across the genome is key to modern genetics. The PRDM9 protein defines recombination hotspots, however megabase-scale recombination patterning is independent of PRDM9. The single round of DNA replication, which precedes recombination in meiosis, may establish these patterns, therefore we d...

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Literature Corpus work: 31f6eea7-4369-515b-982c-b0fd9f69e45b
DOI: 10.1101/2020.09.23.308874

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