Article
Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice.
Genome research - 1 May 2022
Uchimura Arikuni, Matsumoto Hirotaka, Satoh Yasunari, Minakuchi Yohei, Wakayama Sayaka, Wakayama Teruhiko, Higuchi Mayumi, Hashimoto Masakazu, Fukumura Ryutaro, Toyoda Atsushi, Gondo Yoichi, Yagi Takeshi
Abstract excerpt
De novo mutations accumulate with zygotic cell divisions. However, the occurrence of these mutations and the way they are inherited by somatic cells and germ cells remain unclear. Here, we present a novel method to reconstruct cell lineages. We identified mosaic mutations in mice using deep whole-genome sequencing and reconstructed embryonic cell lineages based on the variant allele frequencies of the mutations....
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