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Article

Genetic variation and DNA replication timing, or why is there late replicating DNA?

Evolution; international journal of organic evolution - 1 Nov 2011

Herrick John

Abstract excerpt

Mutation rates vary significantly within the genome and across species. Recent studies revealed a long suspected replication-timing effect on mutation rate, but the mechanisms that regulate the increase in mutation rate as the genome is replicated remain unclear. Evidence is emerging, however, that DNA repair systems, in general, are less efficient in late replicating heterochromatic regions compared to early...

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PMID: 22023572
DOI: 10.1111/j.1558-5646.2011.01407.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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