Article

Striking differences in patterns of germline mutation between mice and humans

2016-10-20

Abstract excerpt

<h4>Summary</h4> Recent whole genome sequencing (WGS) studies have estimated that the human germline mutation rate per basepair per generation (∼1.2−10 −8 ) 1,2 is substantially higher than in mice (3.5-5.4−10 −9 ) 3,4 , which has been attributed to more efficient purifying selection due to larger effective population sizes in mice compared to humans. 5,6,7 . In humans, most germline mutations are paternal i...

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Literature Corpus work: 1fed83f5-519b-5eab-b565-7ffcb6f3c19d
DOI: 10.1101/082297

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