Article

HLA-restricted Biology of Severe Cutaneous Adverse Reactions (SCARs): Dapsone-induced Hypersensitivity as an Example

2025-05-25

Abstract excerpt

HLA proteins are pivotal in antigen processing and adaptive immunity. This study investigates the differential expression of class I and II HLAs in human skin, focusing on HLA-B’s role in drug-induced hypersensitivity syndromes (SCARs). Using RNA expression data from the Human Protein Atlas, we identified HLA-B as the highest expressed class I protein in exposed and non-exposed skin, with significant gender– and a...

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Literature Corpus work: 51097ed3-20f1-5e0e-b81c-b01f7e4bf50c
DOI: 10.1101/2025.05.24.25326117

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