Article

A High-Resolution Landscape of Mutations in the <i>BCL6</i> Super-Enhancer in Normal Human B-Cells

2019-09-26

Abstract excerpt

The super-enhancers (SE) of lineage-specific genes in B-cells are off-target sites of somatic hypermutation. However, the inability to detect sufficient numbers of mutations in normal human B-cells has precluded the generation of a high-resolution mutational landscape of SEs. Here, we captured and sequenced 12 B-cell SEs at single-nucleotide resolution from ten healthy individuals across diverse ethnicities. We de...

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Literature Corpus work: dd8928cb-5da1-5332-bc84-6e098a3bd8b4
DOI: 10.1101/783118

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