Article
Generation of Genomic Alteration from Cytidine Deamination.
Advances in experimental medicine and biology - 1 Jan 2018
Liu Xiaojing, Meng Fei-Long
Abstract excerpt
The sources of genome instability can be attributed to many extra- and exo- cellular factors accompanying various biological processes. In leukemia and lymphomas, the collateral effect of programmed DNA alterations during immune diversification is the major source of genome instability. Cytidine deamination from cytidine (C) to uridine (U) at immunoglobulin (Ig) gene loci is required for initiation of antibody...
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