Article

Super-silencers are crucial for development and carcinogenesis in B cells

2025-06-30

Abstract excerpt

The strength of the repressive histone H3 lysine 27 trimethylation modification signal varies drastically at individual silencers. Focusing on cases of an unusually strong repressive signal in regions that we refer to as super-silencers, we demonstrate that the regions that become B-cell super-silencers are originally associated with gene upregulation during development, and their target genes are highly expressed...

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Literature Corpus work: a2201b00-794d-5e9b-a0d8-6bd82f74d5ba
DOI: 10.1101/2025.06.27.662063

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