Article
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
2019-01-31
Abstract excerpt
<h4>Introductory paragraph</h4> The accumulation of mutations in somatic cells have been implicated as a cause of ageing since the 1950s 1,2 . Yet, attempts to establish a causal relationship between somatic mutations and ageing have been constrained by the lack of methods to directly identify mutational events in primary human tissues. Here we provide detailed, genome-wide mutation frequencies and spectra of hu...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 9884db8b-d3f4-5a92-a90c-02b180bc17a9
- DOI
- 10.1101/535906