Article
Diverse mutational landscapes in human lymphocytes.
Nature - 1 Aug 2022
Machado Heather E, Mitchell Emily, Øbro Nina F, Kübler Kirsten, Davies Megan, Leongamornlert Daniel, Cull Alyssa, Maura Francesco, Sanders Mathijs A, Cagan Alex T J, McDonald Craig, Belmonte Miriam, Shepherd Mairi S, Vieira Braga Felipe A, Osborne Robert J, Mahbubani Krishnaa, Martincorena Iñigo, Laurenti Elisa, Green Anthony R, Getz Gad, Polak Paz, Saeb-Parsy Kourosh, Hodson Daniel J, Kent David G, Campbell Peter J
Abstract excerpt
The lymphocyte genome is prone to many threats, including programmed mutation during differentiation1, antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of single-cell lymphocyte cultures, we sequenced whole genomes from 717 normal naive and memory B and T cells and haematopoietic stem cells. All lymphocyte subsets carried more point mutations...
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