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Article

The APOE Gene is Differentially Methylated in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Foraker Jessica, Millard Steven P, Leong Lesley, Thomson Zachary, Chen Sunny, Keene C Dirk, Bekris Lynn M, Yu Chang-En

Abstract excerpt

The ɛ4 allele of the human apolipoprotein E gene (APOE) is a well-proven genetic risk factor for the late onset form of Alzheimer's disease (AD). However, the biological mechanisms through which the ɛ4 allele contributes to disease pathophysiology are incompletely understood. The three common alleles of APOE, ɛ2, ɛ3 and ɛ4, are defined by two single nucleotide polymorphisms (SNPs) that reside in the coding region...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26402071
DOI: 10.3233/JAD-143060
PMCID: PMC6469491

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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