Article

PhotoAffinity Bits: A Photoaffinity-Based Fragment Screening Platform for Efficient Identification of Protein Ligands

2020-04-01

Abstract excerpt

Advances in genomic analyses enable the identification of new proteins that are associated with disease. To validate these targets, tool molecules are required to demonstrate that a ligand can have a disease-modifying effect. Currently, as tools are reported for only a fraction of the proteome, platforms for ligand discovery are essential to leverage insights from genomic analyses. Fragment screening offers a...

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Literature Corpus work: dd4f600b-9459-51f4-a2b2-e45ea68a9ae8
DOI: 10.26434/chemrxiv.12053445.v1

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