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Article

PHOTACs Enable Optical Control of Protein Degradation

2019-05-31

Abstract excerpt

PROTACs (proteolysis targeting chimeras) are bifunctional molecules that tag proteins for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome. They have emerged as powerful tools to control the levels of specific cellular proteins and are on the verge of being clinically used. We now introduce photoswitchable PROTACs that can be activated with the temporal and spatial precision that...

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Literature Corpus work
3a4d3fc1-ff2d-5425-ab00-224e131329b6
DOI
10.26434/chemrxiv.8206688.v2
Open publication

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PHOTACs Enable Optical Control of Protein DegradationDOI 10.26434/chemrxiv.8206688.v2
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