Expanded Application of a Photoaffinity Probe to Study Epidermal Growth Factor Receptor Tyrosine Kinase with Functional Activity.

doi:10.1021/acs.analchem.2c01340

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Article

Expanded Application of a Photoaffinity Probe to Study Epidermal Growth Factor Receptor Tyrosine Kinase with Functional Activity.

Analytical chemistry - 19 Jul 2022

Deng Hui, Lei Qian, Yang Na, Dai Shengkun, Peng Huipai, Yang Kai, Xiao Zhaolin, Wang Dongpeng, Yu Zhiyi, Li Nan, Li Weimin

Abstract excerpt

The abnormal activation of the epidermal growth factor receptor (EGFR) is strongly associated with cancer invasion and metastasis. Tools and methods are required to study and visualize EGFR activation under (patho)physiological conditions. Here, we report the development of a two-step photoaffinity probe (HX101) by incorporation of a diazirine as a photoreactive group and an alkyne as a ligation handle to...

Topics

Alkynes
ErbB Receptors
Humans
Lung Neoplasms
Mutation
Protein Kinase Inhibitors
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 35729862
DOI: 10.1021/acs.analchem.2c01340

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