Article

Identification of substrates of the protein tyrosine phosphatase PTP1B using <i>in situ</i> site-specific photo-crosslinking

2026-07-07

Abstract excerpt

Protein tyrosine phosphorylation is critical for cellular function, and aberrant phosphorylation is tied to a wide range of human diseases. Identifying the substrates of protein tyrosine phosphatases, the enzymes that erase this modification, is critical to understanding human biology and disease states. The state-of-the-art method for tyrosine phosphatase substrate identification requires the use of mutations tha...

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Literature Corpus work: 3eb146f0-415b-51a3-b950-8d5120e224a1
DOI: 10.64898/2026.07.06.736850

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