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Photoaffinity labeling of protein targets in a complex metazoan: proof-of-concept using a probe for <i>Schistosoma mansoni</i> tubulin

2025-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Treatment of schistosomiasis, a prevalent neglected tropical disease, relies precariously on a single drug. The discovery and development of alternative anti-schistosomal small molecules most often relies on phenotypic (whole-organism) screening, whereas target- or “protein-first”-based discovery options are hampered by a paucity of genetic interrogation strategies and a complex biology. Here, w...

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Literature Corpus work
27225475-1bbf-5cf0-8422-133d612cb188
DOI
10.1101/2025.10.04.680471
Open publication

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Photoaffinity labeling of protein targets in a complex metazoan: proof-of-concept using a probe for <i>Schistosoma mansoni</i> tubulinDOI 10.1101/2025.10.04.680471
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