Recent advances in identifying protein targets in drug discovery.

Abstract excerpt

Phenotype-based screening has emerged as an alternative route for discovering new chemical entities toward first-in-class therapeutics. However, clarifying their mode of action has been a significant bottleneck for drug discovery. For target protein identification, conventionally bioactive small molecules are conjugated onto solid supports and then applied to isolate target proteins from whole proteome. This...

Topics

• Drug Discovery
• Drug Evaluation, Preclinical
• Humans
• Pharmaceutical Preparations
• Phenotype
• Proteins
• Proteolysis
• Small Molecule Libraries