Article
The variation and evolution of complete human centromeres.
Nature - 1 May 2024
Logsdon Glennis A, Rozanski Allison N, Ryabov Fedor, Potapova Tamara, Shepelev Valery A, Catacchio Claudia R, Porubsky David, Mao Yafei, Yoo DongAhn, Rautiainen Mikko, Koren Sergey, Nurk Sergey, Lucas Julian K, Hoekzema Kendra, Munson Katherine M, Gerton Jennifer L, Phillippy Adam M, Ventura Mario, Alexandrov Ivan A, Eichler Evan E
Abstract excerpt
Human centromeres have been traditionally very difficult to sequence and assemble owing to their repetitive nature and large size1. As a result, patterns of human centromeric variation and models for their evolution and function remain incomplete, despite centromeres being among the most rapidly mutating regions2,3. Here, using long-read sequencing, we completely sequenced and assembled all centromeres from a...
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