Article

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

2022-03-26

Abstract excerpt

<h4>Summary</h4> Sulfonylureas (SU) are effective and affordable anti-diabetic drugs. But chronic use leads to secondary failure, limiting their utilization. The mechanism of secondary failure is unknown. Here we identify Cyb5r3 downregulation as a mechanism of SU failure and successfully reverse it. Chronic exposure to SU impairs Cyb5r3 levels and reduces islet glucose utilization with a metabolomics signature c...

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Literature Corpus work: dcd3e322-159f-5767-b5e7-88516c14f69e
DOI: 10.1101/2022.03.23.485508

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