Article

Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes

2021-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Loss of functional β-cell mass is a key factor contributing to the poor glycaemic control in type 2 diabetes. However, therapies that directly target these underlying processes remains lacking. Here we demonstrate that gene expression of neuropeptide Y1 receptor and its ligand, neuropeptide Y, was significantly upregulated in human islets from subjects with type 2 diabetes. Importantly, the redu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 554e5a58-dc6f-5677-bd9c-fad54a17bebe
DOI: 10.1101/2021.05.14.444149

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 DiabetesDOI 10.1101/2021.05.14.444149Read

Genetic and biochemical pathways of β‐cell failure in type 2 diabetesSemantic proximity Read

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.Semantic proximity Read

Recovery of human type 2 diabetes beta cell function associates with transcriptomic signatures that point to novel therapeutic targetsSemantic proximity Read

β-cell NCK1 is reduced in type 2 diabetes, leading to inefficient β-cell UPR and insulin secretion and revealing sex-specific adaptation during metabolic stressSemantic proximity Read

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screenSemantic proximity Read

Differential Effects of Prostaglandin E <sub>2</sub> Production and Signaling through the Prostaglandin EP3 Receptor on Human Beta-cell CompensationSemantic proximity Read

Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose IntoleranceSemantic proximity Read

The role of mu-opioid receptors in pancreatic islet alpha cellsSemantic proximity Read

Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetesSemantic proximity Read

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell massSemantic proximity Read

The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell massSemantic proximity Read

Fatty Acid Transport Protein-2 (FATP2) Inhibition Enhances Glucose Tolerance through α-Cell-mediated GLP-1 SecretionSemantic proximity Read