Article
An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells.
Cell stem cell - 5 Jan 2023
Hermann Florian M, Kjærgaard Maya Friis, Tian Chenglei, Tiemann Ulf, Jackson Abigail, Olsen Lars Rønn, Kraft Maria, Carlsson Per-Ola, Elfving Iina M, Kettunen Jarno L T, Tuomi Tiinamaija, Novak Ivana, Semb Henrik
Abstract excerpt
MODY3 is a monogenic hereditary form of diabetes caused by mutations in the transcription factor HNF1A. The patients progressively develop hyperglycemia due to perturbed insulin secretion, but the pathogenesis is unknown. Using patient-specific hiPSCs, we recapitulate the insulin secretion sensitivity to the membrane depolarizing agent sulfonylurea commonly observed in MODY3 patients. Unexpectedly, MODY3...
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