Article

Itaconate delays type 2 diabetes progression by alkylating RIPK3 to inhibit pancreatic β‑cell failure

2026-08-10

Abstract excerpt

<title>Abstract</title> <p>Dysregulated glucose and lipid metabolism drives β-cell failure, a central event in type 2 diabetes (T2D) pathogenesis; however, effective mechanisms to preserve β-cell mass remain elusive. Through comprehensive metabolomic profiling of human serum, we identified itaconate as a novel metabolic biomarker reduced in T2D patients in a disease severity–dependent manner. Genetic ablation of...

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Literature Corpus work: 597e460d-5a8e-58d3-8801-6b44bd7cf39a
DOI: 10.21203/rs.3.rs-10537918/v1

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