Article

HNF1A deficiency causes reduced calcium levels, accumulation of abnormal insulin granules and uncoupled insulin to C-peptide secretion in a stem cell model of MODY3

2021-06-01

Abstract excerpt

<title>Abstract</title> <p>Mutations in HNF1A cause Maturity Onset Diabetes of the Young type 3 (MODY3), the most prevalent form of monogenic diabetes. Using stem cell-derived pancreatic endocrine cells from human embryonic stem cells (hESCs) with induced hypomorphic mutations in HNF1A, we show that HNF1A orchestrates a transcriptional program required for calcium-dependent insulin secretion. HNF1A-deficient β-ce...

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Literature Corpus work: f30a6adb-ae7c-58e7-86ac-c6d124362e99
DOI: 10.21203/rs.3.rs-509878/v1

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