Back to search

Article

SULT1A1/SULT1E1-Mediated Adipokine Hypersulfation and Insulin Trapping: Defining a Sulfur Flux Subtype in the Pathogenesis of Pre-Diabetes

2025-09-23

Abstract excerpt

Pre-diabetes, a critical phase within the obesity/adiposity-based chronic disease (ABCD) framework, is characterized by hyperinsulinemia and impaired glucose tolerance without classical insulin resistance. This review proposes a novel hypothesis that pathological hypersulfation of adipokines, such as leptin and adiponectin, mediated by sulfotransferases (SULTs), drives insulin trapping, reducing insulin bioavailab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2b465843-1d58-5dda-814c-443475fe71b0
DOI
10.20944/preprints202509.1928.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SULT1A1/SULT1E1-Mediated Adipokine Hypersulfation and Insulin Trapping: Defining a Sulfur Flux Subtype in the Pathogenesis of Pre-DiabetesDOI 10.20944/preprints202509.1928.v1
SULT-Mediated Lipid Sulfation and the LXR/SREBP-1c Axis: Defining a Sulfur Flux Subtype of Treatment-Resistant Obesity/Adiposity-Based Chronic Disease (ABCD)Semantic proximity
Type 5 Diabetes Mellitus: Pathophysiology, Clinical Phenotype, and Nutritional Management.Semantic proximity
mTORC1 syndrome (TorS): unified paradigm for diabetes/metabolic syndromeSemantic proximity
A reference map of the human proinsulin biosynthetic interaction networkSemantic proximity
Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.Semantic proximity
Inter-Organ Crosstalk in MASLD: A Narrative ReviewSemantic proximity
Senescent adipocytes and type 2 diabetes – current knowledge and perspective conceptsSemantic proximity
Important Hormones Regulating Lipid MetabolismSemantic proximity
Thematic Review Series: Lipid Transfer Proteins ABCG5 and ABCG8: more than a defense against xenosterolsSemantic proximity
The "thrifty" gene encoding Ahsg/Fetuin-A meets the insulin receptor: Insights into the mechanism of insulin resistance.Semantic proximity
Phenotype-Directed Precision Therapeutics: A Framework for Multi-Agonist Therapy in Obesity, MASH and Cardio-Renal-Metabolic DisordersSemantic proximity
Phenotype-Directed Precision Therapeutics: A Framework for Multi-Agonist Therapy in Obesity, MASH and Cardio-Renal-Metabolic DisordersSemantic proximity
Select a neighboring publication to make it the new centre.