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Article

Characterization of two MODY2 mutations with different susceptibility to activation.

Biochemical and biophysical research communications - 4 Sept 2015

Langer Sara, Platz Christian, Waterstradt Rica, Baltrusch Simone

Abstract excerpt

Glucokinase plays a key role in glucose sensing in pancreatic beta cells and in liver metabolism. Heterozygous inactivating glucokinase mutations cause the autosomal dominantly inherited MODY2 subtype of maturity-onset diabetes of the young. The goal of this study was to elucidate the pathogenicity of the recently described glucokinase mutants L304P and L315H, located in an alpha-helix and connecting region,...

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Source

Identifiers

PMID: 26208450
DOI: 10.1016/j.bbrc.2015.07.088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of two MODY2 mutations with different susceptibility to activation.PMID 26208450Read ↗

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