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Article

Discovery of a drug candidate for GLIS3-associated diabetes.

Nature communications - 11 Jul 2018

Amin Sadaf, Cook Brandoch, Zhou Ting, Ghazizadeh Zaniar, Lis Raphael, Zhang Tuo, Khalaj Mona, Crespo Miguel, Perera Manuradhi, Xiang Jenny Zhaoying, Zhu Zengrong, Tomishima Mark, Liu Chengyang, Naji Ali, Evans Todd, Huangfu Danwei, Chen Shuibing

Abstract excerpt

GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous attempts to recapitulate disease-relevant phenotypes in GLIS3-/- β-like cells have been unsuccessful. Here, we develop a "minimal component" protocol to generate late-stage pancreatic progenitors (PP2) that differentiate to mono-hormonal glucose-responding...

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Identifiers

PMID: 29992946
DOI: 10.1038/s41467-018-04918-x
PMCID: PMC6041295

Genes

GLIS3

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