Article

SULT-Mediated Lipid Sulfation and the LXR/SREBP-1c Axis: Defining a Sulfur Flux Subtype of Treatment-Resistant Obesity/Adiposity-Based Chronic Disease (ABCD)

2025-09-22

Abstract excerpt

Treatment-resistant obesity/adiposity-based chronic disease (ABCD), affecting approximately 20-30% of cases, poses a significant challenge beyond traditional insulin resistance, often manifesting with preserved insulin sensitivity in early stages. This review driven hypothesis proposes that SULT-mediated lipid sulfation, via enzymes like SULT1A1, SULT1E1, and SULT2B1, drives this phenotype through LXR/SREBP-1c act...

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Literature Corpus work: 4184a90a-629b-59c9-864a-1be3294e7445
DOI: 10.20944/preprints202509.1778.v1

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