Article

Genotoxic formaldehyde and lipid aldehydes are sources of DNA damage in keratinocytes

2025-11-14

Abstract excerpt

The Fanconi anemia (FA) pathway is vital for the repair of DNA interstrand crosslinks (ICLs), which are caused by a variety of endogenous and exogenous genotoxins including reactive aldehydes. Patients with pathogenic variants in the FA pathway are predisposed to early-onset, aggressive malignancies, especially leukemia and head and neck, esophageal, and anogenital squamous cell carcinomas (SCCs). Prior studies ha...

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Literature Corpus work: dc9a55f2-d6bc-528a-a29b-8f466da39c34
DOI: 10.1101/2025.11.13.688345

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