Article

Endogenous formaldehyde scavenges cellular glutathione resulting in cytotoxic redox disruption

2020-05-15

Abstract excerpt

Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking. We show here that FA can cause cellular damage beyond genotoxicity by triggering oxidative stress, which is prevented by the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR). Mechanistically, we determine that endogenous FA reacts with the redox-active thiol group of...

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Identifiers and source

Literature Corpus work: 82e1f2b2-42bc-5ef9-bdce-dae3456dd98a
DOI: 10.1101/2020.05.14.090738

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