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Article

Enhanced formaldehyde clearance ameliorates differentiation-induced genotoxicity in Fanconi anemia mutant cells.

Cell reports - 23 Jun 2026

Wu Jinghang, Yang Fan, Du Xiaotong, Shi Siqian, Li Landing, Wang Zhilin, Wang Jiayi, Yi Can, Duan Yuejia, Xiao Yajing, Cheng Sirui, Yin Xianghuijun, Wang Xinxin, Jin Jianping, Lin Shixian, Zheng Liangyu, Li Lei

Abstract excerpt

Fanconi anemia (FA) is a genetic disorder characterized by aplastic anemia and bone marrow failure arising from DNA crosslinking repair deficiencies. During hematopoietic differentiation, formaldehyde accumulates as a byproduct of transcriptional reprogramming, generating DNA crosslinks that abort differentiation and progressively deplete the hematopoietic hierarchy in the absence of FA pathway function. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42213781
DOI: 10.1016/j.celrep.2026.117449

Genes

ALDH8A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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