Article
Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model.
Molecular biology reports - 1 Oct 2023
Mu Anfeng, Cao Zimu, Huang Denggao, Hosokawa Hiroshi, Maegawa Shingo, Takata Minoru
Abstract excerpt
BACKGROUND: Fanconi anemia (FA) is a devastating hereditary disorder for which we desperately need a novel therapeutic strategy. It is caused by mutations in one of at least 22 genes in the FA pathway and is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. The FA pathway is required for the efficient repair of damaged DNA, including interstrand cross-links (ICL)....
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