Article
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Molecular cell - 17 Dec 2020
Dingler Felix A, Wang Meng, Mu Anfeng, Millington Christopher L, Oberbeck Nina, Watcham Sam, Pontel Lucas B, Kamimae-Lanning Ashley N, Langevin Frederic, Nadler Camille, Cordell Rebecca L, Monks Paul S, Yu Rui, Wilson Nicola K, Hira Asuka, Yoshida Kenichi, Mori Minako, Okamoto Yusuke, Okuno Yusuke, Muramatsu Hideki, Shiraishi Yuichi, Kobayashi Masayuki, Moriguchi Toshinori, Osumi Tomoo, Kato Motohiro, Miyano Satoru, Ito Etsuro, Kojima Seiji, Yabe Hiromasa, Yabe Miharu, Matsuo Keitaro, Ogawa Seishi, Göttgens Berthold, Hodskinson Michael R G, Takata Minoru, Patel Ketan J
Abstract excerpt
Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly shortened lifespans and develop leukemia. Hematopoiesis is disrupted profoundly, with a reduction of hematopoietic stem cells and common lymphoid progenitors causing a severely depleted...
Topics
- Adolescent
- Alcohol Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Aldehydes
- Animals
- Child
- Child, Preschool