Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotoxic aldehydes in the hematopoietic system

11 Feb 2022

Abstract excerpt

Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem cells and blood production. To protect against aldehydes, mammals have evolved a family of enzymes to detoxify aldehydes, and the Fanconi anemia DNA repair pathway to process aldehyde-induced DNA damage. Loss of either protection mechanisms in humans results in defective hematopoiesis and predisposition to leukemia. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35148375
DOI: 10.1182/blood.2019004316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotoxic aldehydes in the hematopoietic systemPMID 35148375Read ↗

ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes.Semantic proximity Read ↗

DNA damage and repair in the hematopoietic systemSemantic proximity Read ↗

Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.Semantic proximity Read ↗

Enhanced formaldehyde clearance ameliorates differentiation-induced genotoxicity in Fanconi anemia mutant cells.Semantic proximity Read ↗

ALDH9A1 Deficiency as a Source of Endogenous DNA Damage that Requires Repair by the Fanconi Anemia PathwaySemantic proximity Read ↗

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.Semantic proximity Read ↗

Comprehensive review on Fanconi anemia: insights into DNA interstrand cross-links, repair pathways, and associated tumorsSemantic proximity Read ↗

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease ProgressionSemantic proximity Read ↗

Aldehyde dehydrogenases in acute myeloid leukemiaSemantic proximity Read ↗

Genotoxic formaldehyde and lipid aldehydes are sources of DNA damage in keratinocytesSemantic proximity Read ↗

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.Semantic proximity Read ↗

The DNA damage response pathway in normal hematopoiesis and malignancies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.