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Article

ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes.

Mutation research - 1 Jan 2000

Woo Anthony Yiu-Ho, Jia Lina

Abstract excerpt

Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion called interstrand crosslink (ICL). Aldehyde-metabolizing enzymes such as aldehyde dehydrogenases (ALDHs) and the Fanconi anemia (FA) pathway constitute the main defense lines against aldehyde-induced genotoxicity. Biallelic mutations of genes in...

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Identifiers

PMID: 38944932
DOI: 10.1016/j.mrfmmm.2024.111870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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