Article

Long-term Outcomes of Prophylactic Total Gastrectomy in Patients with Hereditary Diffuse Gastric Cancer

2025-12-12

Abstract excerpt

<h4>Importance</h4> Hereditary diffuse gastric cancer (HDGC) is predominantly due to germline CDH1 variants and confers a high lifetime risk of diffuse gastric cancer (DGC). Prophylactic total gastrectomy (PTG) is thought to prevent DGC but has potential long-term functional, nutritional and quality-of-life (QOL) sequelae. <h4>Objective</h4> We report the clinical, pathological and long-term weight and QOL out...

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Literature Corpus work: dc8f08da-f363-59c7-973a-330ebc266c90
DOI: 10.64898/2025.12.11.25342067

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