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Article

Outcomes after prophylactic gastrectomy for hereditary diffuse gastric cancer.

The British journal of surgery - 1 Jan 2018

van der Kaaij R T, van Kessel J P, van Dieren J M, Snaebjornsson P, Balagué O, van Coevorden F, van der Kolk L E, Sikorska K, Cats A, van Sandick J W

Abstract excerpt

BACKGROUND: Patients with hereditary diffuse gastric cancer and a CDH1 mutation have a 60-80 per cent lifetime risk of developing diffuse gastric cancer. Total prophylactic gastrectomy eliminates this risk, but is associated with considerable morbidity. The effectiveness (removal of all gastric mucosa) and outcomes of this procedure were evaluated retrospectively. METHODS: All consecutive individuals undergoing a...

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Source

Identifiers

PMID: 29341148
DOI: 10.1002/bjs.10754

Genes

CDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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