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Adolescents and young adults with germline CDH1 variants and the risk of overtreatment

4 Jan 2025

Abstract excerpt

BACKGROUND: Adolescents and young adults (AYA) with germline CDH1 variants are at risk of overtreatment when precancer lesions are detected with endoscopic screening. We characterize diffuse-type gastric cancer prevalence and survival in AYA managed with prophylactic total gastrectomy (PTG) or endoscopic surveillance. METHODS: Prospective cohort study of 188 individuals aged 39 and younger enrolled from January...

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PMID: 39760880
DOI: 10.1093/jnci/djaf002

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