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Hereditary diffuse gastric cancer: the evolution of a cancer syndrome

16 Jun 2025

Abstract excerpt

ABSTRACT Hereditary Diffuse Gastric Cancer (HDGC) is a high risk cancer syndrome caused predominantly by germline mutations in the CDH1 gene. HDGC is characterised by a lifetime risk of advanced diffuse‐type gastric (stomach) cancer of up to 70%, and an additional 40% lifetime risk of lobular breast cancer in women. Since the first description of HDGC in three whānau Māori in 1998, our understanding of this...

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PMID: 40756848
DOI: 10.1080/03036758.2025.2511007

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