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Article

The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study.

Annals of surgery - 1 Jul 2014

Worster Elizabeth, Liu Xinxue, Richardson Susan, Hardwick Richard H, Dwerryhouse Sarah, Caldas Carlos, Fitzgerald Rebecca C

Abstract excerpt

BACKGROUND: The advice to individuals with identified CDH1 mutations is generally to undertake prophylactic total gastrectomy (PTG). This study evaluated the effect of PTG on health-related quality of life (HRQL) in asymptomatic individuals with identified CDH1 mutations at high risk for gastric cancer. METHODS: Individuals with hereditary diffuse gastric cancer (HDGC) were recruited to a prospective, multicenter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24424140
DOI: 10.1097/SLA.0000000000000446

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study.PMID 24424140Read ↗

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Short and long-term outcomes of prophylactic total gastrectomy in 54 consecutive individuals with germline pathogenic mutations in the CDH1 gene.Semantic proximity Read ↗

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Laparoscopic Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer in CDH1 Mutation Carriers.Semantic proximity Read ↗

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